Specific Graft Treatment Solution Enhances Vascular Endothelial Function

Background: Saline is still the most widely used storage and rinsing solution for vessel grafts during cardiac surgery despite knowing evidence of its negative influence on human endothelial cell function. Aim this study was to assess effect DuraGraft©, an intraoperative graft treatment solution, saphenous vein segments further elaborate vasoprotective rat aortic in comparison saline. Methods: Human Saphenous (HSV) from patients undergoing aortocoronary bypass (n = 15), were randomized DuraGraft© 15) or saline before storage. Each segment divided into two subsegmental parts evaluation. These as well stored underwent assessment vascular function a multichamber isometric myograph system Krebs-Henseleit (KHS), physiologic organ buffer solution. Results: Potassium-Chloride (KCL)-induced contraction depicted tendency towards increase when treated with compared preservation HSV (23.02 ± 14.77 vs 14.44 9.13 mN, p 0.0571). Vein preserved showed significant improvement endothelium-dependent vasorelaxation response cumulative concentrations bradykinin (p < 0.05). Rat significantly impaired vasoconstriction (3.59 4.20, 0.0001) KHS 0.0001). Conclusions: demonstrated favorable relaxation indicating Clinical Trial Registration Number: NCT04614077.